aldosterone in serum/plasma

Indications

• evaluation of hyperaldosteronism

Reference interval

• supine: 2-5 ng/dL (60-140 pmol/L)
• standing: 7-20 ng/dL (194-555 pmol/L)

* assumes normal sodium intake

Increases

• primary hyperaldosteronism
  • bilateral adrenal hyperplasia
  • aldosterone-secreting adrenal adenoma
• secondary hyperaldosteronism
  • laxative abuse
  • diuretic abuse
  • heart failure
  • cirrhosis of the liver with ascites
  • nephrotic syndrome
  • idiopathic cyclic edema
  • Bartter' syndrome
  • hypervolemia due to hemorrhage
  • renal juxtaglomerular hyperplasia with K+ wastage
  • renal hemangiopericytoma producing renin
  • malignant hypertension of renal origin
  • thermal stress
  • pregnancy
  • starvation after 10 days
  • COPD
• drugs
  • angiotensin, estrogens, laxatives, loop diuretics, metoclopramide, oral contraceptives, spironolactone, thiazides, K+, serotonin reuptake inhibitors (SSRI),

Decreases

• Liddle syndrome
• drugs
  • aminoglutethimide, licorice, direct renin inhibitors NSAIDs
  • alpha-adrenergic receptor agonists
  • beta-adrenergic receptor antagonists
  • ACE inhibitors, dihydropyridine calcium channel blockers

Methods

• see aldosterone in serum/urine

Specimen

• plasma (heparin or EDTA) or serum
  • store frozen
  • stable for 2 years at -20 degrees C in airtight container

More general terms

• aldosterone in body fluid

More specific terms

• aldosterone in serum/plasma standing
• aldosterone in serum/plasma supine

Additional terms

• aldosterone (Electrocortin, Aldocortin)
• angiotensin-1/renin activity in plasma
• renin-angiotensin-aldosterone axis

Component of

• captopril-renin stimulation test
• intravenous salt loading test
• fludrocortisone suppression test
• aldosterone renal clearance
• aldosterone+ renin panel in/plasma
• Aldosterone/Renin in serum/plasma

Patient information

aldosterone in serum patient information