laxative
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Classification
- bulk-forming laxative
- osmotic laxative
- stool softener
- stimulant laxative
- opioid antagonist
- secretagogue
* see constipation for further description of laxative classes
* only polyethylene glycol, bisacodyl, sodium picosulfate, linaclotide, plecanatide & prucalopride with strong evidence of efficacy[1]
Indications
- treatment of constipation
- bowel preparation for colonoscopy
Complications
- regular laxative use associated with increased risk of all-cause dementia, especially with use of multiple laxative types or osmotic laxative[2]
More general terms
More specific terms
- bisacodyl (Dulcolax tablets, suppository)
- casanthranol
- casanthranol/docusate (Peri-Colace)
- cascara sagrada
- castor oil (Purge)
- docusate
- Duphalac
- glycerol; glycerin (Osmoglyn)
- guar gum
- lactitol; lactitolum; importal; lactosit (Pizensy)
- lactulose (Chronulac, Cephulac)
- linaclotide (Linzess)
- lubiprostone (Amitiza)
- magnesium citrate (citrate of magnesia)
- magnesium hydroxide (Milk of Magnesia)
- methylcellulose (Citrucel, Murocel)
- mineral oil (Kondremul)
- naldemedine (Symproic)
- naloxegol (Movantik)
- phenolphthalein (Ex-Lax)
- polycarbophil (Equalactin, Konsyl, FiberCon, Fiberlax, Fibertab)
- polyethylene glycol [PEG] (Go-Lytely, CoLyte, Miralax, Glycolax)
- prucalopride (Resotran, Motegrity)
- psyllium (Metamucil, Fiberall)
- senna; sennosides,(Senokot, Geri-kot)
- sodium biphosphate (Fleet phospho soda enema)
- suflave
Additional terms
References
- ↑ 1.0 1.1 Chang L et al. American Gastroenterological Association-American College of Gastroenterology clinical practice guideline: Pharmacological management of chronic idiopathic constipation. Gastroenterology 2023 Jun; 164:1086. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37211380 https://www.gastrojournal.org/article/S0016-5085(23)00513-9/fulltext
- ↑ 2.0 2.1 Yang Z, Wei C, Li X et al Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants. Neurology. 2023 Apr 18;100(16):e1702-e1711. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36813729 PMCID: PMC10115504 Free PMC article.
- ↑ Prescriber's Letter Comparison of Laxatives Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=180614&pb=PRL (subscription needed) http://www.prescribersletter.com