linaclotide (Linzess)

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Indications

Dosage

  • 145 ug PO QD, taken on an empty stomach, at least 30 minutes before the 1st meal of the day

Capsule: 72 ug, 145 ug, 290 ug

Storage

  • store in orginal container
  • must be protected from moisture
  • original container has a desiccant[5]

Adverse effects

Mechanism of action

More general terms

References

  1. Lembo AJ et al Two Randomized Trials of Linaclotide for Chronic Constipation N Engl J Med 2011; 365:527-536 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21830967
  2. FDA News Release: Aug. 30, 2012 FDA approves Linzess to treat certain cases of irritable bowel syndrome and constipation http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm317505.htm
  3. 3.0 3.1 Chey WD et al. Linaclotide for irritable bowel syndrome with constipation: A 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am J Gastroenterol 2012 Nov; 107:1702 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22986437 <Internet> http://www.nature.com/ajg/journal/v107/n11/full/ajg2012254a.html
    Rao S et al. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am J Gastroenterol 2012 Nov; 107:1714. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22986440 <Internet> http://www.nature.com/ajg/journal/v107/n11/full/ajg2012255a.html
  4. 4.0 4.1 4.2 Prescriber's Letter 19(12): 2012 New Drug: Linzess (Linaclotide) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=281204&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 Prescriber's Letter 21(6): 2014 Oral Meds to Keep in Original Containers Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300622&pb=PRL (subscription needed) http://www.prescribersletter.com
  6. 6.0 6.1 Brooks M FDA Approves First Treatment for Constipation in Kids. Medscape. June 12, 2023 https://www.medscape.com/viewarticle/993074

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