mineral oil (Kondremul)

Introduction

Tradename: Kondremul.

Indications

• relief of constipation
• bowel preparation
• ophthalmic
  • dry eyes, Sjogren's syndrome

Contraindications

pregnancy-category C

safety in lactation ?

Dosage

5-45 mL PO QHS, 5-15 mL dose for child

Pharmacokinetics

• absorption from the GI tract is minimal
• 30-60% of the emulsion may be absorbed from the intestine, especially in combination with docusate (Colace)
• bowel relief generally occurs within 6-8 hours
• elimination: Not absorbed.

Adverse effects

• with long-term therapy can decrease absorption of fat-soluble vitamins
• aspiration in patients at risk
• may cause mineral oil leaking from rectum

Drug interactions

• docusate in combination causes increased systemic absorption of mineral oil & may lead to fatty liver

Mechanism of action

lubricant laxative

More general terms

• laxative

Component of

• mineral oil/tetracaine
• mineral oil/petrolatum/polyvinyl alcohol ophthalmic
• mineral oil/petrolatum/phenylephrine/shark liver oil
• mineral oil/petrolatum/phenylephrine/preparation h
• mineral oil/petrolatum/phenylephrine
• mineral oil/oatmeal
• carboxymethylcellulose/mineral oil/petrolatum
• mineral oil/pramoxine/witch hazel/zinc oxide
• mineral oil/phenylephrine/shark liver oil/white petrolatum
• lanolin/mineral oil/white petrolatum
• carboxymethylcellulose/mineral oil/white petrolatum
• mineral oil/phenylephrine/white petrolatum
• mineral oil/white petrolatum
• magnesium hydroxide/mineral oil
• ceresin wax/mineral oil/petrolatum (Absorbase)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3777159
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6503