lactulose (Chronulac, Cephulac)

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Introduction

Tradenames: Chronulac, Cephulac.

Indications

Contraindications

pregnancy-category B

safety in lactation ?

Dosage

May be taken as is or diluted with water or fruit juice

Liquid: 10 g/15 mL (240, 480, 1920 mL).

Pharmacokinetics

  • onset of bowel relief occurs within 24-48 hours
  • < 3% of dose is absorbed
  • unabsorbed lactulose reaches the colon to form lactic acid & small amounts of acetic & formic acid

Adverse effects

Drug interactions

Mechanism of action

Notes

  • milk & milk products may contain significant amounts of lactulose

More general terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 Department of Veterans Affairs, VA National Formulary
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. PubMed Search PubMed search: lactulose

Database