ephrin-B3; EPH-related receptor tyrosine kinase ligand 8; LERK-8; EPH-related receptor transmembrane ligand ELK-L3 (EFNB3, EPLG8, LERK8)

Function

• may play a pivotal role in forebrain function
• binds to, & induces the collapse of, commissural axons & growth cones in vitro
• may play a role in constraining the orientation of longitudinally projecting axons
• interacts with GRIP1 & GRIP2
• binds to Nipah virus G protein

Structure

• belongs to the ephrin family

Compartment

• membrane; single-pass type 1 membrane protein

Expression

• highly expressed in brain
  • expressed in embryonic floor plate, roof plate & hindbrain segments

More general terms

• ephrin B or ephrin B ligand

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1949
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1949
• OMIM: https://mirror.omim.org/entry/602297
• UniProt: http://www.uniprot.org/uniprot/Q15768.html