glutamate receptor-interacting protein 2; GRIP-2 (GRIP2 KIAA1719)

Function

• may play a role as a localized scaffold for the assembly of a multiprotein signaling complex & as mediator of the trafficking of its binding partners at specific subcellular location in neurons (putative)
• interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 & GRIPAP1
• can form homomultimers & heteromultimers with GRIP1
• interacts with the C-terminal tail of PRLHR

Structure

• PDZ 5 mediates the C-terminal binding of GRIA2 & GRIA3
• PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1
• PDZ 7 mediates interaction with CSPG4 (putative)
• belongs to the GRIP2 family
• contains 7 PDZ domain (DHR domain)s

Compartment

• cytoplasm (putative)
• membrane, peripheral membrane (putative)

Alternative splicing

• named isoforms=3
• intron retention

More general terms

• glutamate receptor-interacting protein (GRIP)
• oligomerizing protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9C0E4.html