prolactin-releasing peptide receptor; PrRP receptor; PrRPR; G-protein coupled receptor 10; hGR3 (PRLHR, GPR10, GR3)

Function

• receptor for prolactin-releasing peptide (PrRP)
• implicated in lactation, regulation of food intake & pain-signal processing
• interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 & PICK1
• interacts with PDZ domains 4 & 5 of GRIP1 & with the PDZ domain of PICK1

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• only detected in the pituitary gland & in all cell types of pituitary adenomas
• repressed by bromocriptine, a dopamine agonist

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• prolactin-releasing peptide ((PrRP, prolactin-releasing hormone, PRLH, PRH))

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2834
• OMIM: https://mirror.omim.org/entry/600895
• UniProt: http://www.uniprot.org/uniprot/P49683.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2834