GRIP1-associated protein 1; GRASP-1 (GRIPAP1 ,KIAA1167)

Function

• guanine nucleotide exchange factor for the ras family of G proteins
• proteolytically cleaved by caspase-3 (putative)
• interacts with GRIP1, GRIP2 & AMPA receptors

Compartment

early endosome

Alternative splicing

named isoforms=4

Expression

• neuron-specific

Pathology

• antibodies against GRIPAP1 have been found in sera of a patient who developed Raynaud's syndrome & telangiectasias

More general terms

• guanine nucleotide exchange factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56850
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56850
• OMIM: https://mirror.omim.org/entry/300408
• UniProt: http://www.uniprot.org/uniprot/Q4V328.html