Ephrin type-B receptor 2; tyrosine-protein kinase receptor EPH-3; DRT; receptor protein-tyrosine kinase HEK5; ERK; tyrosine-protein kinase TYRO5; renal carcinoma antigen NY-REN-47 (EPHB2; DRT; EPHT3; EPTH3; ERK; HEK5; TYRO5)

Function

• receptor for members of the ephrin-B family
• acts as a tumor suppressor
• ligand-activated form interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain
• binds RASGAP through the juxtamembrane Tyr
• interacts with PRKCABP & GRIP1 (putative)
• ligand (ephrin B2) binding of the ephB2 receptor in the postsynaptic membrane leads to binding of a src family protein to the ephB2 receptor, activation of src & phosphorylation of the NR2B subunit of the NMDA receptor at 3 phospho-Tyr sites; this in turn leads to an increase in Ca+2 permeability of the NMDA receptor; through this mechanism, the ephB2 receptor may be involved in synaptic plasticity
• EphB2 receptors may also induce clustering of NMDA receptors

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
• contains 2 fibronectin F3 modules
• contains 1 protein kinase domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in brain, heart, lung, kidney, placenta, pancreas, liver & skeletal muscle
• preferentially expressed in fetal brain

Pathology

• defects in EPHB2
  • progression of prostate cancer
  • prostate cancer metastasis to the brain

More general terms

• ephB receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2048
• OMIM: https://mirror.omim.org/entry/176807
• OMIM: https://mirror.omim.org/entry/600997
• OMIM: https://mirror.omim.org/entry/603688
• UniProt: http://www.uniprot.org/uniprot/P29323.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2048