ephrin type-A receptor 3; ephA3 receptor; tyrosine-protein kinase receptor ETK1; HEK; HEK4; tyrosine-protein kinase TYRO4 (EPHA3, ETK, ETK1, HEK, TYRO4)

Function

• receptor for members of the ephrin-A family
• binds to ephrin-A2, ephrin-A3, ephrin-A4 ephrin-A5
• lymphoid function (putative)

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
• contains 2 fibronectin F3 modules
• contains 1 protein kinase domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

• isoform 1: cell membrane
• isoform 2: secreted

Alternative splicing

named isoforms=2

Expression

widely expressed, highest level in placenta

Pathology

defects in EPHA3 may be a cause of colorectal cancer

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• ephA receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2042
• OMIM: https://mirror.omim.org/entry/114500
• OMIM: https://mirror.omim.org/entry/179611
• UniProt: http://www.uniprot.org/uniprot/P29320.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2042