K+ voltage-gated channel subfamily H member 6; ether-a-go-go-related gene K+ channel 2; ERG-2; Eag-related protein 2; ether-a-go-go-related protein 2; hERG-2; hERG2; voltage-gated K+ channel subunit Kv11.2 (KCNH6 ERG2)

Function

• pore-forming (alpha) subunit of voltage-gated K+ channel
• elicits a slowly activating, rectifying current
• channel properties may be modulated by cAMP & subunit assembly
• the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
• heteromultimers with KCNH2/ERG1 & KCNH7/ERG3 (putative)

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.2/KCNH6 sub-subfamily
• contains 1 cyclic nucleotide-binding domain
• contains 1 PAC (PAS-associated C-terminal) domain
• contains 1 PAS (PER-ARNT-SIM) domain

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in prolactin-secreting adenomas

More general terms

• K+ channel subfamily H
• transmembrane 6 protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81033
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81033
• OMIM: https://mirror.omim.org/entry/608168
• UniProt: http://www.uniprot.org/uniprot/Q9H252.html