cyclic nucleotide-binding site

Introduction

Domain of about 120 amino acid residues present in roteins that bind cyclic nucleotides (cAMP or cGMP). There are 6 invariant amino acid residues in this domain, 3 of which are Gly thought to be essential for a distinctive 8-stranded, antiparallel beta-barrel. The domain also contains 3 alpha-helices.

More general terms

• purine nucleotide-binding site
• allosteric site
• domain

More specific terms

• cAMP-binding site
• cGMP-binding site