short transient receptor potential channel 4 (TrpC4, Trp-related protein 4, hTrp-4, hTrp4, TRPC4)

Function

• forms a receptor-activated non-selective Ca+2 channel (putative)
• regulated by phosphatidylinositol 2nd messenger system activated by receptor tyrosine kinases or G-protein coupled receptors
• may also be activated by intracellular Ca+2 store depletion
• isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR)
• interacts with NHERF

Structure

• belongs to the transient receptor family, STrpC subfamily
• contains 2 ANK repeats

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

• expressed in placenta > heart, pancreas, kidney, brain
• isoform alpha predominant isoform
• isoform beta not found in pancreas, brain

More general terms

• transmembrane 6 protein
• Ca+2 channel

Database

• OMIM: https://mirror.omim.org/entry/603651
• UniProt: http://www.uniprot.org/uniprot/Q9UBN4.html