splicing factor 3B subunit 1 (spliceosome associated protein 155, SAP 155, SF3b155, pre-mRNA splicing factor SF3b 155 kD subunit, SF3B1)

Function

• subunit of the splicing factor SF3B
• identified in the spliceosome C complex
• SF3B1 interacts directly with the splicing factor U2AF
• phosphorylated form interacts with PPP1R8
• phosphorylation occurs concomitantly with the splicing catalytic steps.
• phosphorylation on Thr-244, Thr-248 & Thr-313 by cyclin-dependent kinases promotes interaction with PPP1R8 during mitosis

Structure

• belongs to the SF3B1 family
• contains 11 HEAT repeats

Compartment

• nucleus speckle
• during mitosis, transiently dispersed from the nuclear speckles to the cytoplasm

More general terms

• splicing factor; snRNP-associated protein
• protein subunit
• phosphoprotein

Component of

• splicing factor 3B (SF3B)
• spliceosome C complex

Database

• OMIM: https://mirror.omim.org/entry/605590
• UniProt: http://www.uniprot.org/uniprot/O75533.html