WICH complex

Function

• chromatin remodeling complex that mobilizes nucleosomes & reconfigures irregular chromatin to a regular nucleosomal array structure
• regulates the transcription of various genes
• role in RNA polymerase 1 & RNA polymerase 3 transcription
• mediates the histone H2AX phosphorylation at Tyr-142
• role in the maintenance of chromatin structures during DNA replication processes

Structure

• subunits: SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A & DDX21

More general terms

• molecular complex

Additional terms

• B-WICH complex