RUN & FYVE domain-containing protein 1 (FYVE-finger protein EIP1, zinc finger FYVE domain-containing protein 12, La-binding protein 1, Rab4-interacting protein, RUFY1, RABIP4, ZFYVE12)

Function

• binds phospholipid vesicles containing phosphatidylinositol 3-phosphate via FYVE-type zinc finger domain
• early endosomal trafficking
• interacts with BMX, SSB, & GTP-activated RAB4 & RAB5
• phosphorylation on Tyr-389 &/or Tyr-400 is required for interaction with BMX & endosomal targeting

Structure

• contains 1 FYVE-type zinc finger.
• contains 1 RUN domain

Compartment

cytoplasm, early endosomal membrane, peripheral membrane

Alternative splicing

named isoforms=3

Expression

• broadly expressed
• highest levels in lung, testis, kidney, brain

More general terms

• RUN & FYVE domain-containing protein (RUFY)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96T51.html