Lupus La protein; Sjoegren syndrome type B antigen; SS-B; La ribonucleoprotein; La autoantigen (SSB)

Function

• La protein plays a role in the transcription of RNA polymerase 3
• it is most probably a transcription termination factor
• binds to the 3' termini of virtually all nascent RNA polymerase 3 transcripts
• associated with precursor forms of RNA polymerase 3 transcripts including tRNA & 4.5S, 5S, 7S, & 7-2 RNAs
• phosphorylated
• interacts with DDX15
• may interact with RUFY1

Structure

• phosphorylation sites are at the C-terminal part of the protein
• the N-terminus is blocked
• contains 1 HTH La-type RNA-binding domain
• contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus (probable)

Pathology

• sera from patients with systemic lupus erythematosus (SLE) often contain La protein autoantibodies (anti-SSB)

More general terms

• RNA-binding protein
• nuclear protein
• antigen
• phosphoprotein

Additional terms

• SSB/La Ab in serum

Database

• UniProt: http://www.uniprot.org/uniprot/P05455.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6741
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6741
• OMIM: https://mirror.omim.org/entry/109090