small G protein signaling modulator 3; RUN & TBC1 domain-containing protein 3, Rab-GTPase-activating protein-like protein; RabGAPLP; Merlin-associated protein (SGSM3, MAP, RABGAPLP, RUTBC3)

Function

• may play a cooperative role in NF2-mediated growth suppression of cells
• may act as a modulator of small G protein RAB- & RAP-mediated neuronal signal transduction & vesicular transportation pathways
• interacts with GJA1
• interaction with GJA1 induces its degradation (putative)
• interacts via its RUN domain with the C-terminal region of NF2
• interacts with RAB3, RAB4, RAB5, RAB8, RAP1A, RAP1B, RAP2A & RAP2B

Structure

• belongs to the small G protein signaling modulator family
• contains 1 Rab-GAP TBC domain
• contains 1 RUN domain
• contains 1 SH3 domain

Alternative splicing

named isoforms=2

More general terms

• rab GTPase-activating protein (rab-GAP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96HU1.html