rap1b proto-oncogene protein; Ras-related protein rap-1b; GTP-binding protein smg p21B (RAP1B)
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Function
- activated by guanine nucleotide-exchange factor EPAC2 (cAMP-dependent manner)
- interacts with SGSM1, SGSM2 & SGSM3
Structure
belongs to the small GTPase superfamily, Ras family
Compartment
- cell membrane, cytoplasm
- may shuttle between plasma membrane & cytosol
More general terms
References
- ↑ Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
- ↑ Seizinger BR, Breakefield XO. The role of 'tumor suppressor' genes in neural tumors. Trends Neurosci. 1990 Jan;13(1):3-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1688673
- ↑ Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL. Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. 1991 May 3;65(3):429-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/201897511
- ↑ UniProt http://www.uniprot.org/uniprot/P61224.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RAP1BID273.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/rap1b/