rap2A proto-oncogene protein; Ras-related protein rap-2a; RbBP-30 (RAP2A)

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Function

activated by guanine nucleotide-exchange factors EPAC & EPAC2 (cAMP-dependent)
activated by MRGEF
interacts with PLCE1
interacts with SGSM1, SGSM2, SGSM3 & ARHGAP29
the GTP-bound form of RAP2A interacts with RUNDC3A

Structure

the effector domain mediates the interaction with RUNDC3A
belongs to the small GTPase superfamily, Ras family

Compartment

cell membrane; lipid-anchor; cytoplasmic side (putative)

More general terms

rap2 proto-oncogene protein

References

↑ UniProt http://www.uniprot.org/uniprot/P10114.html
↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RAP2AID274.html
↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203

Database

UniProt: http://www.uniprot.org/uniprot/P10114.html
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5911
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5911
OMIM: https://mirror.omim.org/entry/179540

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