rap guanine nucleotide exchange factor 3; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI; exchange factor directly activated by cAMP 1; exchange protein directly activated by cAMP 1; EPAC 1; rap1 guanine-nucleotide-exchange factor directly activated by cAMP (RAPGEF3, CGEF1, EPAC, EPAC1)

Function

• guanine nucleotide exchange factor (GEF) for RAP1A & RAP2A small GTPases that is activated by binding cAMP

Structure

• the DEP domain is involved in membrane localization independent from regulation by cAMP
• contains 1 cyclic nucleotide-binding domain
• contains 1 DEP domain
• contains 1 N-terminal Ras-GEF domain
• contains 1 Ras-GEF domain

Compartment

• endomembrane system

Alternative splicing

named isoforms=2

Expression

• widely expressed with highest levels in adult kidney, heart, thyroid & brain, & fetal kidney

Notes

• uncertain whether Met-1 or Met-43 is the initiator

More general terms

• guanine nucleotide exchange factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10411
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10411
• OMIM: https://mirror.omim.org/entry/606057
• UniProt: http://www.uniprot.org/uniprot/O95398.html