rap1A proto-oncogene protein, Krev-1 proto-oncogene protein, small GTP-binding protein 21A (smg p21A) or rap1A6 proto-oncogene protein

Introduction

Forms high affinity complex with ras-GAP.

Function

• induces morphological reversion of a cell line transformed by a Ras oncogene
• counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs & RAF in a competitive manner
• Rap1A may function by competing with ras proteins for interaction with their effectors (i.e. raf1, etc.)
• in its GTP-bound form, interacts with PLCE1 & RADIL
• interacts with SGSM1, SGSM2 & SGSM3
• activated by guanine nucleotide-exchange factors EPAC & EPAC2 (cAMP-dependent manner)
• activated by MRGEF

Structure

belongs to the small GTPase superfamily, Ras family

Compartment

cell membrane; lipid-anchor

Notes

• the synonym krev1 derives from the ability of rap1A to reverse cellular transformation induced by K-ras & Smgp21

More general terms

• ras-associated protein (rap)

Database

• UniProt: http://www.uniprot.org/uniprot/P62834.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5906
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5906
• OMIM: https://mirror.omim.org/entry/179520