Rap guanine nucleotide exchange factor 5 (guanine nucleotide exchange factor for Rap1, related to Epac, Repac, M-Ras-regulated Rap GEF, MR-GEF, RAPGEF5, GFR, KIAA0277, MRGEF)

Function

• guanine nucleotide exchange factor for RAP1A, RAP2A & MRAS/M-Ras-GTP
• its association with MRAS inhibits Rap1 activation

Structure

• contains 1 N-terminal Ras-GEF domain
• contains 1 Ras-GEF domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

widely expressed with highest levels in brain

More general terms

• guanine nucleotide exchange factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q92565.html