Ras-related protein M-Ras; Ras-related protein R-Ras3 (MRAS, RRAS3)

Function

• may serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation
• weakly activates the MAP kinase pathway
• interacts with RGL3 (putative)
• forms a multiprotein complex with SHOC2, Raf (RAF1) & protein phosphatase 1 (PPP1CA, PPP1CB & PPP1CC)

Structure

• belongs to the small GTPase superfamily, Ras family

Compartment

• cell membrane; lipid-anchor; cytoplasmic side (putative)

Expression

• expression restricted to brain & heart
• induced by IL-9
• not induced by IL-2 or IL-4

More general terms

• ras subfamily protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22808
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22808
• OMIM: https://mirror.omim.org/entry/608435
• UniProt: http://www.uniprot.org/uniprot/O14807.html