Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3, RGL3)

Function

• guanine nucleotide exchange factor (GEF) for Ral-A
• effector of GTPase HRas & Ras-related protein M-Ras (putative)
• negatively regulates Elk-1-dependent gene induction downstream of HRas & MEKK1 (putative)
• interacts with GTP-bound forms of RIT1, HRAS & MRAS

Structure

• Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity (putative)
• contains 1 N-terminal Ras-GEF domain
• contains 1 Ras-associating domain
• contains 1 Ras-GEF domain

More general terms

• phosphoprotein
• ral guanine nucleotide exchange factor (ral-GEF, RALGDS)

Database

• UniProt: http://www.uniprot.org/uniprot/Q3MIN7.html