serine/threonine protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Function

• one of 3 alternate catalytic subunits of protein phosphatase 1 (PP1)
• component of the PTW/PP1 phosphatase complex
• component of the MLL5-L complex
• part of a complex containing PPP1R15B, PP1 & NCK1/2 (putative)
• interacts with PPP1R7 & PPP1R12C
• interacts with PPP1R8

Cofactor:

• binds 1 iron ion per subunit (putative)
• binds 1 Mn+2 per subunit (putative)

Inhibition:

• inhibited by the toxins okadaic acid, tautomycin & microcystin Leu-Arg (putative)

phosphoprotein + H2O = a protein + phosphate

[myosin light-chain] phosphate + H2O = [myosin light-chain] + phosphate

Structure

• belongs to the PPP phosphatase family, PP-1 subfamily

Compartment

• cytoplasm, nucleus, nucleoplasm, nucleolus
• highly mobile in cells & can be relocalized through interaction with targeting subunits
• in the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles

More general terms

• phosphatase-1 catalytic subunit

Additional terms

• MLL5-L complex
• phosphatase-1 (PP1)
• PTW/PP1 phosphatase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5500
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5500
• OMIM: https://mirror.omim.org/entry/600590
• UniProt: http://www.uniprot.org/uniprot/P62140.html