protein phosphatase 1 regulatory subunit 12C (protein phosphatase 1 myosin-binding subunit of 85 kD, protein phosphatase 1 myosin- binding subunit p85, PPP1R12C, MBS85)

Function

• regulates myosin phosphatase activity
• interacts via its N-terminus with PPP1CB
• interacts with IL16
• interacts with the coiled-coil domain of MRIP
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 4 ANK repeats

Compartment

• cytoplasm, along actomyosin filaments & stress fibers

Alternative splicing

named isoforms=4

Expression

• ubiquitously expressed
• highly expressed in heart

More general terms

• protein phosphatase-1 regulatory subunit
• ankyrin repeat domain protein (ANKRD)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5477
• UniProt: http://www.uniprot.org/uniprot/Q9BZL4.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54776