myosin phosphatase Rho-interacting protein; Rho-interacting protein 3; M-RIP; RIP3; p116Rip (MRIP, MPRIP, KIAA0864, RHOIP3)

Function

• targets myosin phosphatase to the actin cytoskeleton
• required for regulation of the actin cytoskeleton by RhoA & ROCK1
• depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin
• overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells
• binds F-actin through its N-terminus
• binds RHOA, PPP1R12A/MBS & PPP1R12C/MBS85 through adjacent coiled coil domains

Structure

contains 2 PH domains

Compartment

cytoplasm, colocalizes with F-actin

Alternative splicing

named isoforms=3

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6WCQ1.html