serine/threonine protein phosphatase PP1-alpha catalytic subunit; PP-1A (PPP1CA, PPP1A)

Function

• one of 3 alternate catalytic subunits of protein phosphatase 1 (PP1)
• component of the PTW/PP1 phosphatase complex
• component of the MLL5-L complex
• part of a complex containing PPP1R15B, PP1 & NCK1/2
• forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX & NCOA5
• interacts with PPP1R9A & PPP1R9B
• interacts with YLPM1
• interacts with NOM1 & PPP1R8
• interacts with HHV-1 ICP34.5
• interacts with PPP1R16B.
• interacts with RPSA only in the presence of PPP1R16B
• interacts with PPP1R10/PNUTS & PPP1R8
• interacts with WDR82 in the presence of PPP1R10/PNUTS

Cofactor:

• binds 1 iron ion per subunit (putative)
• binds 1 Mn+2 per subunit (putative)

phosphoprotein + H2O = a protein + phosphate

Structure

• belongs to the PPP phosphatase family, PP-1 subfamily

Compartment

• cytoplasm, nucleus, nucleoplasm, nucleolus
• primarily nuclear & largely excluded from the nucleolus
• highly mobile in cells & can be relocalized through interaction with targeting subunits
• NOM1 plays a role in targeting this protein to the nucleolus
• in the presence of PPP1R8, relocalizes from the nucleus to nuclear speckles

More general terms

• phosphatase-1 catalytic subunit

Additional terms

• MLL5-L complex
• phosphatase-1 (PP1)
• PTW/PP1 phosphatase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5499
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5499
• OMIM: https://mirror.omim.org/entry/176875
• UniProt: http://www.uniprot.org/uniprot/P62136.html