protein phosphatase-1 regulatory subunit 10 (phosphatase 1 nuclear targeting subunit, MHC class I region proline rich protein CAT53, FB19 protein, PP1-binding protein of 114 kD, p99, PPP1R10, CAT53, FB19, PNUTS)
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Function
- inhibits PPP1CA & PPP1CC.
- inhibits PPP1CA only when phosphorylated
- binds to mRNA, single-stranded DNA
Expression
- expressed in olfactory cortex, piriform cortex, entorhinal cortex, hippocampus
Pathology
- high expression in regions of Alzheimer's disease pathology [2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q8TAE6.html
- ↑ 2.0 2.1 Raha-Chowdhury R, Andrews SR, Gruen JR. CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease. Brain Res Mol Brain Res. 2005 Jul 29;138(1):70-83. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15894402