interleukin enhancer-binding factor 3; nuclear factor of activated T-cells 90 kD; NF-AT-90; double-stranded RNA-binding protein 76; DRBP76; translational control protein 80; TCP80; nuclear factor associated with dsRNA; NFAR; M-phase phosphoprotein 4 (ILF3, MPP4, DRBF, MPHOSPH4, NF90)

^[1]

Function

may facilitate double-stranded RNA-regulated gene expression at the level of post-transcription
can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) & other mRNAs
functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes
can regulate protein arginine N-methyltransferase 1 activity
may regulate transcription of the IL2 gene during T-cell activation
can promote formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA
interacts with FUS & SMN proteins & with PRMT1
forms a complex with ILF2
can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 & the heterodimeric complex of G22P1/KU70 & XRCC5/KU80
forms a heteromeric complex with ZNF346 & ILF3
found in a nuclear export complex with XPO5, ILF3, Ran & double-stranded RNA or double-stranded minihelix VA1 RNA
found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 & double-stranded RNA
interacts with XPO5 & ZNF346
phosphorylated by RNA-dependent protein kinase (EIF2AK2)
methylated by protein arginine N-methyltransferase 1
Arg-609 is dimethylated, probably to asymmetric dimethylarginine