RNA-binding protein FUS; proto-oncogene protein FUS; proto-oncogene protein TLS; translocated in liposarcoma protein; POMp75; 75 kD DNA-pairing protein (FUS, TLS)

Function

• binds both single-stranded & double-stranded DNA
• promotes ATP-independent annealing of complementary single-stranded DNAs & D-loop formation in superhelical double-stranded DNA
• may play a role in maintenance of genomic integrity
• component of nuclear riboprotein complexes
• interacts with ILF3, TDRD3 & SF1
• interacts through its C-terminus with FUSIP1
• interacts with SARNP

Structure

• Arg-216 & Arg-218 are dimethylated, probably to asymmetric dimethylarginine
• belongs to the RRM TET family
• contains 1 RanBP2-type Zn+2 finger
• contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus

Alternative splicing

named isoforms=2; long, short

Expression

ubiquitous

Pathology

• chromosomal translocation t(12;16)(q13;p11) involving FUS with DDIT3 is a cause of a form of malignant myxoid liposarcoma
• chromosomal translocation t(16;21)(p11;q22) involving FUS with ERG is a cause of acute myeloid leukemia (AML)
• chromosomal translocation t(12;16)(q13;p11.2) involving FUS with ATF1 is associated with angiomatoid fibrous histiocytoma; translocation generates a chimeric FUS/ATF1 protein
• defects in FUS are the cause of amyotrophic lateral sclerosis type 6
• FUS deposits in the brain of some patients with frontotemporal dementia (FTD)

More general terms

• RNA-binding protein
• zinc finger protein
• nuclear protein
• proto oncogene protein

Database

• UniProt: http://www.uniprot.org/uniprot/P35637.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2521
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2521
• OMIM: https://mirror.omim.org/entry/137070
• OMIM: https://mirror.omim.org/entry/608030
• OMIM: https://mirror.omim.org/entry/612160
• OMIM: https://mirror.omim.org/entry/151900