tudor domain-containing protein 3 (TDRD3)

Function

• scaffolding protein
• specifically recognizes & binds dimethylarginine-containing proteins
• in nucleus, acts as a coactivator: recognizes & binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a & H4R3me2a) & recruits proteins at these arginine-methylated loci
• in cytoplasm, may play a role in the assembly &/or disassembly of mRNA stress granules & in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins
• component of mRNA stress granules
• interacts with FMR1, FXR1, FXR2, EWSR1, FUS, SERBP1, EEF1A1 & DDX3X or DDX3Y & with the small nuclear ribonucleoprotein- associated proteins SNRPB & SNRPN
• interacts with Lys-48-linked tetra-ubiquitin
• does not interact with monoubiquitin or Lys-63-linked ubiquitin chains

Structure

• the Tudor domain specifically recognizes & binds asymmetric dimethylation of histone H3 Arg-17 (H3R17me2a) & histones H4 Arg-3, 2 tags for epigenetic transcriptional activation
• contains 1 Tudor domain
• contains 1 UBA domain

Compartment

• cytoplasm, nucleus
• predominantly cytoplasmic
• associated with actively translating polyribosomes & with mRNA stress granules

Alternative splicing

named isoforms=3

Expression

• detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas

More general terms

• tudor domain-containing protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81550
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81550
• OMIM: https://mirror.omim.org/entry/614392
• UniProt: http://www.uniprot.org/uniprot/Q9H7E2.html