PAI1 RNA-binding protein 1; PAI-RBP1; SERPINE1 mRNA-binding protein 1 (SERBP1, PAIRBP1, CGI-55)

Function

• may play a role in the regulation of mRNA stability
• binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay
• interacts with CHD3 & TDRD3

Compartment

• cytoplasm, nucleus, perinuclear region

Alternative splicing

• named isoforms=4
• at least one isoform may be due to competing acceptor splice site

Expression

• expressed at high level in the heart, skeletal muscle & kidney
• expressed at low levels in placenta, liver & brain

More general terms

• nuclear protein
• phosphoprotein

Additional terms

• plasminogen activator inhibitor 1; PAI; PAI-1; endothelial plasminogen activator inhibitor; Serpin E1 (SERPINE1 PAI1 PLANH1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26135
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26135
• OMIM: https://mirror.omim.org/entry/607378
• UniProt: http://www.uniprot.org/uniprot/Q8NC51.html