chromodomain-helicase-DNA-binding protein 3; CHD-3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kD protein; Mi2-alpha; zinc finger helicase; hZFH (CHD3)

Function

• component of the histone deacetylase NuRD complex
• interacts with TRIM28 & SERBP1
• interacts (via its C-terminal) with HABP4
• interacts with PCNT;
  • interaction regulates centrosome integrity

ATP + H2O = ADP + phosphate

Structure

• belongs to the SNF2/RAD54 helicase family
• contains 2 chromo domains
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 2 PHD-type Zn+2 fingers

Compartment

• nucleus, cytoplasm, cytoskeleton
• associates with centrosomes in interphase & mitosis

Alternative splicing

named isoforms=2

Expression

widely expressed

Pathology

• one of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis

More general terms

• chromodomain-helicase-DNA-binding protein
• zinc finger protein
• phosphoprotein

Component of

• nucleosome remodeling & histone deacetylation (NuRD) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1107
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1107
• OMIM: https://mirror.omim.org/entry/602120
• UniProt: http://www.uniprot.org/uniprot/Q12873.html