intracellular hyaluronan-binding protein 4 (IHABP4, Ki-1/57 intracellular antigen, HABP4)
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Function
- role in nuclear functions including remodeling of chromatin & regulation of transcription (putative)
- interacts with C-terminus of CHD3
- interacts via its C-terminal region with GNB2L1, interaction abolished by phosphorylation
- interacts with TP53/p53
- able to bind hyaluronan; however, its intracellular localization suggests that this interaction may not be relevant in vivo
- phosphorylation by phorbol 12-myristate 13-acetate (PMA)- activated PKC isoforms at Thr-354 & Thr-375 (probable) results in exit of HABP4 from the nucleus
Compartment
- cytoplasm, nucleus
- ransported into nuclear compartment in activated leukocytes
Alternative splicing
named isoforms=2
Expression
- expressed in brain, heart & kidney > skeletal muscle
- expression in activated but not resting leukocytes
Pathology
- expressed in a variety of tumor cell lines