guanine nucleotide-binding protein subunit beta-2-like 1; guanine nucleotide-binding protein subunit beta-like protein 12.3; receptor of activated protein kinase C 1; RACK1; receptor for activated C kinase; cell proliferation-inducing gene 21 protein; Human lung cancer oncogene 7 protein; HLC-7 (GNB2L1)

Function

• seems to bind protein kinase C acting as an intracellular receptor to anchor activated PKC to the cytoskeleton
• may be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1
• together with KRT1 & ITGB1, serves as a platform for SRC activation or inactivation
• may play a role in the developing brain & neuronal differentiation
• binds SLC9A3R1
• forms a ternary complex with TRIM63 & PRKCE
• interacts with HABP4 & KRT1

Structure

• the WD repeats domain 5 mediates interaction with TRIM63
• belongs to the WD repeat G protein beta family
• contains 7 WD repeats

Compartment

• cell membrane
• located on plasma membrane of neuroblastoma NMB7 cells

More general terms

• receptor
• WD repeat protein family
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10399
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10399
• OMIM: https://mirror.omim.org/entry/176981
• UniProt: http://www.uniprot.org/uniprot/P63244.html