plasminogen activator inhibitor 1; PAI; PAI-1; endothelial plasminogen activator inhibitor; Serpin E1 (SERPINE1 PAI1 PLANH1)

Function

• serine protease inhibitor
• acts as 'bait' for tissue plasminogen activator, urokinase, protein C & matriptase-3/TMPRSS7
• its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis
• inactivated by proteolytic attack of the urokinase & tissue-type plasminogen activator (TPA), cleaving the 369-Arg-|-Met-370 bond
• forms protease inhibiting heterodimer with TMPRSS7
• interacts with VTN
• binds LRP1B
• binding is followed by internalization & degradation

Structure

belongs to the serpin family

Compartment

secreted

Expression

• found in plasma & platelets, endothelial cells
• found in hepatoma & fibrosarcoma cells
• induced by hypoxia

Pathology

• defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency*

high concentrations of SERPINE1

• seem to contribute to development of venous thrombosis
• does not seem to contribute to development of arterial thrombosis

* heterozygousity of null SERPINE1 allele associated with longevity

More general terms

• tissue plasminogen activator inhibitor; tPA inhibitor (TPA-I)

Additional terms

• PAI1 RNA-binding protein 1; PAI-RBP1; SERPINE1 mRNA-binding protein 1 (SERBP1, PAIRBP1, CGI-55)
• plasminogen activator
• plasminogen activator inhibitor 2; PAI-2; monocyte Arg-serpin; placental plasminogen activator inhibitor; Serpin B2; urokinase inhibitor (SERPINB2, PAI2, PLANH2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5054
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5054
• OMIM: https://mirror.omim.org/entry/173360
• OMIM: https://mirror.omim.org/entry/613329
• UniProt: http://www.uniprot.org/uniprot/P05121.html