tissue plasminogen activator inhibitor; tPA inhibitor (TPA-I)

Function

• complexes with catalytic site of urokinase or tissue-type plasminogen activator (tPA) to form inactive complex
• inefficient when tPA is fibrin bound

Notes

• relationship to protein C inhibitor (SERPINA5) is unclear

More general terms

• plasma protein
• serine protease inhibitor; serpin

More specific terms

• plasminogen activator inhibitor 1; PAI; PAI-1; endothelial plasminogen activator inhibitor; Serpin E1 (SERPINE1 PAI1 PLANH1)
• plasminogen activator inhibitor 2; PAI-2; monocyte Arg-serpin; placental plasminogen activator inhibitor; Serpin B2; urokinase inhibitor (SERPINB2, PAI2, PLANH2)