urokinase; urokinase-type plasminogen activator; U-plasminogen activator; uPA (PLAU)
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Function
- proteolytic enzyme produced naturally by the renal parenchymal cells that promotes thrombolysis by converting plasminogen to plasmin
- specific cleavage of Arg-|-Val bond in plasminogen to form plasmin
- inhibited by SERPINA5
- phosphorylation of Ser-158 & Ser-323 abolishes proadhesive ability but does not interfere with receptor binding
- found in high & low molecular mass forms
- each consists of two chains, A & B
- the high molecular mass form contains a long chain A which is cleaved to yield a short chain A
- forms heterodimer with SERPINA5
- binds LRP1B
- binding is followed by internalization & degradation
- interacts with MRC2
- interacts with PLAUR
Structure
- belongs to the peptidase S1 family
- contains 1 EGF-like domain
- contains 1 kringle domain
- contains 1 peptidase S1 domain
Compartment
- secreted
- normally present in urine
Alternative splicing
named isoforms=2
Expression
- secreted by renal parenchymal cells
- expressed in the prostate gland & prostate cancers
Pathology
- defects in PLAU are the cause of Quebec platelet disorder
Pharmacology
- available under the name Abbokinase (Abbott)
- used for therapy of venous thrombosis or venous thromboembolism
More general terms
- plasminogen activator
- peptide precursor
- multisubunit protein
- fibrinolytic agent (thrombolytic agent)
- enzymatic agent
- glycoprotein
- phosphoprotein
More specific terms
- Abbokinase (urokinase)
- prourokinase; contains: urokinase-type plasminogen activator long chain A; urokinase-type plasminogen activator short chain A; urokinase-type plasminogen activator chain B (PLAU)
- urokinase A fragment
- urokinase B fragment
Additional terms
References
- ↑ Clinical Diagnosis and Management by Laboratory Methods, 18th ed, J.B. Henry (ed), W.B. Saunders, Philadelphia, PA, 1991 pg 739
- ↑ UniProt http://www.uniprot.org/uniprot/P00749.html
- ↑ Wikipedia; Note: urokinase entry http://en.wikipedia.org/wiki/urokinase
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/plau/