macrophage mannose receptor 2 (urokinase receptor-associated protein, endocytic receptor 180, CD280 antigen, MRC2, ENDO180, KIAA0709, UPARAP)

Function

• endocytotic lectin receptor (Ca+2-dependent)
• internalizes glycosylated ligands via clathrin-mediated endocytosis
• role in plasminogen activation, regulating extracellular PLAUR/PLAU, & thus regulation of protease activity at the cell surface (putative)
• uptake & degradation of extracellular collagen matrices co-operating with matrix metalloproteinases (putative)
• interacts with COL1A1, PLAUR, PLAU, collagen-5
• phosphorylated

Structure

• N-glycosylated
• contains 8 C-type lectin domains
  • C-type lectin domains 3 to 8 are not required for Ca+2-dependent binding of mannose, fucose & N-acetylglucosamine
  • C-type lectin domain 2 is responsible for sugar-binding (Ca+2-dependent)
• contains 1 fibronectin type-II domain
  • fibronectin type-II domain mediates collagen-binding
• contains 1 ricin B-type lectin domain
  • ricin B-type lectin domain contacts with the 2nd C-type lectin domain (putative)

Compartment

membrane

Expression

• ubiquitous
• low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus & colon
• expressed in endothelial cells, fibroblasts & macrophages
• highly expressed in fetal lung & kidney

Pathology

• may play role in cancer progression & other chronic tissue destructive diseases acting on collagen turnover

More general terms

• cell surface receptor
• Ca+2 binding protein
• CD antigen
• lectin

Additional terms

• macrophage
• macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; CD206 (MRC1, CLEC13D)
• mannose

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UBG0.html