urokinase plasminogen activator surface receptor; uPAR; U-PAR; monocyte activation antigen Mo3; CD87 (PLAUR, MO3, UPAR)

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Function

Structure

  • monomer (probable).
  • contains 3 UPAR/Ly6 domains

Compartment

Alternative splicing

named isoforms=3

Expression

* expression may be related to inflammation, complement activation, coagulation & TGF-beta signaling [5]

Pathology

Pharmacology

* uPAR is a putative biomarker of senescent cells[5]

Laboratory

More general terms

Additional terms

References

  1. UniProt http://www.uniprot.org/uniprot/Q03405.html
  2. http://www.pathologyoutlines.com/cdmarkers.html 20 May 2003
  3. 3.0 3.1 3.2 Protein Reviews on the Web http://mpr.nci.nih.gov/prow/guide/1928485002_g.htm
  4. SeattleSNPs http://pga.gs.washington.edu/data/plaur/
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Amor C, Fernandez-Maestre I, Chowdhury S et al Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nat Aging. 2024 Jan 24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38267706 https://www.nature.com/articles/s43587-023-00560-5

Database