urokinase plasminogen activator surface receptor; uPAR; U-PAR; monocyte activation antigen Mo3; CD87 (PLAUR, MO3, UPAR)
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Function
- receptor for urokinase plasminogen activator (uPA)
- role in localizing & promoting plasmin formation
- uPA bound to uPAR can lead to conversion of plasminogen to plasmin which becomes bound to adjacent plasma membrane receptors
- negatively regulated by uPA
- receptors for uPA & plasmin have been localized to leading edges of migrating leukocytes & tumor cells leading to enzymatic activity of plasmin (which is dependent on uPA) causing hydrolysis of surrounding extra-cellular matrix proteins; thus, uPAR expression & level of bound uPA have been implicated in inflammatory cell invasion & tumor cell metastasis[3]
- CD87 may also contribute to beta-2-integrin-dependent adherence & chemotaxis[3]
- interacts with MRC2
Structure
- monomer (probable).
- contains 3 UPAR/Ly6 domains
Compartment
Alternative splicing
named isoforms=3
Expression
- T cells
- NK cells
- monocytes
- myeloid cells, neutrophils
- dendritic cells
- endothelial cells
- fibroblasts
- smooth muscle cells
- keratinocytes
- placental trophoblasts
- hepatocytes
- bronchial epithelium (low levels)[5]
* expression may be related to inflammation, complement activation, coagulation & TGF-beta signaling [5]
Pathology
- breast carcinoma
- colon carcinoma
- prostate carcinoma
- melanoma
- may have role in metastases
- expression may be related to inflammation, complement activation, coagulation & TGF-beta signaling[5]
- putative role in human aging
- plasma soluble UPAR positively correlates with the rate of aging in humans[5]
- age-related increase in UPAR in liver, adipose tissue, skeletal muscle & pancreas[5]
- parallel increase in senecence-associated beta-galactosidase
Pharmacology
- clearance of cell surface uPAR-containing cells* with CAR T-cell therapy may prevent &/or attenuate age-related degenerative pathology[5]
* uPAR is a putative biomarker of senescent cells[5]
Laboratory
- elevated plasma soluble urokinase plasminogen activator receptor may be used to assess indication for anakinra in treatment of Covid-19 pneumonia
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q03405.html
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 20 May 2003
- ↑ 3.0 3.1 3.2 Protein Reviews on the Web http://mpr.nci.nih.gov/prow/guide/1928485002_g.htm
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/plaur/
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Amor C, Fernandez-Maestre I, Chowdhury S et al Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nat Aging. 2024 Jan 24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38267706 https://www.nature.com/articles/s43587-023-00560-5
Database
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5329
- Kegg: http://www.genome.jp/dbget-bin/www_bget?son:SO_1
- OMIM: https://mirror.omim.org/entry/173391
- UniProt: http://www.uniprot.org/uniprot/Q03405.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5329