low-density lipoprotein receptor-related protein 1B; LRP-1B; low-density lipoprotein receptor-related protein-deleted in tumor; LRP-DIT (LRP1B, LRPDIT)

Function

• cell surface protein that binds & internalize ligands in the process of receptor-mediated endocytosis
• binds LRPAP1, PLAU, PLAT & SERPINE1
• binding is followed by internalization & degradation of ligands

Structure

• belongs to the LDLR family
• contains 14 EGF-like domains
• contains 32 LDL-receptor class A domains
• contains 36 LDL-receptor class B repeats

Compartment

• membrane, single-pass type 1 membrane protein (putative)

Expression

• expressed in thyroid gland & in salivary gland, as well as in adult & fetal brain

Pathology

• gene preferentially inactivated in non-small-cell lung cancer

More general terms

• low-density lipoprotein (LDL) receptor related protein (LRP)
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53353
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53353
• OMIM: https://mirror.omim.org/entry/608766
• UniProt: http://www.uniprot.org/uniprot/Q9NZR2.html