alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; low density lipoprotein receptor-related protein-associated protein 1; RAP; p39RAP (LRPAP1, A2MRAP)
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Function
- interacts with LRP1/alpha-2-macroglobulin receptor & glycoprotein 330
- present on cell surface forming a complex with LRP1 heavy & light chains
- binds LRP1B
- binding is followed by internalization & degradation
- may serve as a chaperone for the LRP1
- p39rap modifies (inhibits) binding of ligands to the 515 KD subunit of LRP
Structure
- N-glycosylated
- belongs to the alpha-2-MRAP family
Compartment
- endoplasmic reticulum. cytoplasm, cell surface
- intracellular & associated with cell surface receptors
- found in the endoplasmic reticulum
Pathology
- in complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membranous glomerulonephritis
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P30533.html
- ↑ Williams SE et al A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor- related protein. Multiple regulatory sites for 39-kDa receptor-associated protein. J Biol Chem 267:9035 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1374383