fibrinolytic agent (thrombolytic agent)

Indications

• thrombolytic therapy
  • chest pain > 30 min & < 6 hours unrelieved by nitroglycerin & associated with at least 1 mm ST elevation in 2 contiguous leads with reciprocal ST segment depression
  • massive pulmonary embolism with sysolic blood pressure < 90 mm Hg, or evidence of poor tissue perfusion despite adequate resuscitation

Contraindications

• major surgery or trauma within 10 days.
• history of CNS hemorrhage, tumor, aneurysm or AVM.
• hemorrhagic CVA within 6 months.
• coma
• bleeding diathesis
• prolonged CPR (> 10 min).
• pregnancy
• GI bleed within 3 months.
• severe, uncontrolled hypertension (> 200/110).
• prior streptokinase with 1 year (streptokinase only).

More general terms

• hematologic agent
• cardiovascular agent

More specific terms

• Abbokinase (urokinase)
• anistreplase (APSAC, Eminase)
• heparin
• plasmin; fibrinolysin
• plasminogen; contains: plasmin heavy chain A; activation peptide; angiostatin; plasmin light chain B (PLG)
• recombinant tissue plasminogen activator (TPA, t-PA, rt-PA,)
• streptokinase (Streptase, Kabikinase, Streptozyme)
• tranexamic acid (Cyklokapron, Lysteda)
• urokinase; urokinase-type plasminogen activator; U-plasminogen activator; uPA (PLAU)

Additional terms

• antithrombotic agent