plasminogen activator inhibitor 2; PAI-2; monocyte Arg-serpin; placental plasminogen activator inhibitor; Serpin B2; urokinase inhibitor (SERPINB2, PAI2, PLANH2)

Function

• inhibits urokinase-type plasminogen activator
• monocyte derived PAI-2 is distinct from endothelial cell- derived PAI-1
• the signal sequence is not cleaved

interacts with PSMB1

Structure

belongs to the serpin family, Ov-serpin subfamily

Compartment

cytoplasm. secreted, extracellular space

Expression

• produced by monocytes

More general terms

• tissue plasminogen activator inhibitor; tPA inhibitor (TPA-I)
• glycoprotein

Additional terms

• plasminogen activator
• plasminogen activator inhibitor 1; PAI; PAI-1; endothelial plasminogen activator inhibitor; Serpin E1 (SERPINE1 PAI1 PLANH1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5055
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5055
• OMIM: https://mirror.omim.org/entry/173390
• UniProt: http://www.uniprot.org/uniprot/P05120.html