suppressor of tumorigenicity 14 protein; matriptase; membrane-type serine protease 1; MT-SP1; prostamin; serine protease 14; serine protease TADG-15; tumor-associated differentially-expressed gene 15 protein (ST14, PRSS14, SNC19, TADG15)

Function

• degrades extracellular matrix
• has trypsin-like activity
  • cleaves synthetic substrates with Arg or Lys at the P1 position
  • prefers small side-chain amino acids, such as Ala & Gly, at the P2 position
• interacts with CDCP1
• may interact with TMEFF1

Structure

• belongs to the peptidase S1 family
• contains 2 CUB domains
• contains 4 LDL-receptor class A domains
• contains 1 peptidase S1 domain

Compartment

• membrane
• single-pass type 2 membrane protein (probable)

Pathology

• defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis
• may play a role in breast cancer invasion & metastasis

More general terms

• serine protease
• membrane protein
• anti-oncoprotein (tumor suppressor protein)
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6768
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6768
• OMIM: https://mirror.omim.org/entry/606797
• OMIM: https://mirror.omim.org/entry/610765
• UniProt: http://www.uniprot.org/uniprot/Q9Y5Y6.html