tomoregulin-1 (transmembrane protein with EGF-like & one follistatin-like domain, TR-1, H7365, TMEFF1, C9orf2)

Function

• may inhibit NODAL & BMP signaling during neural patterning
• may be a tumor suppressor in brain cancers
• may interact with ST14

Structure

• belongs to the tomoregulin family
• contains 1 EGF-like domain
• contains 2 Kazal-like domains

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

• expressed predominantly in brain
• lower levels in heart, placenta & skeletal muscle

Pathology

• down-regulated in brain tumors as compared to control brain tissues

More general terms

• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/603421
• UniProt: http://www.uniprot.org/uniprot/Q8IYR6.html