Transmembrane protein with EGF-like & two follistatin-like domains 2 (transmembrane protein containing epidermal growth factor & follistatin domains, tomoregulin, TR, hyperplastic polyposis protein 1, TMEFF2, HPP1, TENB2, TPEF, UNQ178/PRO204)

Function

• may be a novel survival factor for hippocampal & mesencephalic neurons

Structure

• N-glycosylated
• contains chondroitin sulfate glycosaminoglycans
• contains 1 EGF-like domain
• contains 2 Kazal-like domains

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• highly expressed in the adult & fetal brain, spinal cord & prostate
• in brain, expression in all regions of the adult brain except pituitary, highest level in amygdala & corpus callosum
• expressed in the pericryptal myofibroblasts & other stromal cells of normal colonic mucosa

Pathology

• expressed in prostate carcinoma
• more expressed in normal colon than in colorectal cancer

More general terms

• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/605734
• UniProt: http://www.uniprot.org/uniprot/Q9UIK5.html